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Updated: May 18, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
What's New in Pediatric Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated
Lorenzo D'Antiga1, Emer Fitzpatrick2, Rohit Kohli3
1Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy; Department of Medicine and Surgery, University of Milano - Bicocca, Milan, Italy.
Abstract:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease in children, with rising prevalence and substantial systemic consequences. This review synthesizes recent advances in pediatric MASLD and its severe form, metabolic dysfunction-associated steatohepatitis (MASH), with emphasis on new insights in epidemiology, pathogenesis, and disease burden. Diagnostic evaluation in children remains particularly challenging, requiring integration of clinical, laboratory, imaging, and histologic data, while balancing accuracy, feasibility, and risk. Progress will depend on the development of pediatric-specific tools, equitable access to care, and rigorously designed clinical trials to guide future management.
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