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[Chronic keratitis and autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome - a case report]
Klinische Monatsblatter Fur Augenheilkunde
|January 24, 2002
Summary
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome (APECED) can cause severe keratitis. A dexamethasone and gentamycin treatment stabilized corneal infiltrates in a young patient, offering comfort despite the condition's poor prognosis.
Area of Science:
- Ophthalmology
- Genetics
- Immunology
Background:
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome (APECED) is a rare genetic disorder.
- APECED is associated with ocular manifestations, including severe keratitis, potentially leading to blindness.
- Ocular complications described in APECED include conjunctivitis, uveitis, cataracts, and optic nerve atrophy.
Observation:
- A case report details an 11-year-old girl with APECED experiencing chronic keratoconjunctivitis for 6.5 years.
- The patient presented with corneal infiltrates, peripheral scarring, and neovascularization.
- Symptoms included recurrent conjunctivitis, photophobia, and epiphora.
Findings:
- Local application of dexamethasone and gentamycin was the most effective therapy for the patient.
- This treatment regimen stabilized corneal infiltrates and improved patient comfort.
- No adverse side effects were observed during the treatment period.
Implications:
- The findings suggest a potential therapeutic option for managing APECED-associated keratitis.
- Despite successful stabilization, the search for treatments with fewer side effects, such as glaucoma or cataracts, continues.
- Further research is needed to explore long-term efficacy and alternative treatments for APECED ocular complications.