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[Long-term prospective study of hepatitis B virus carriers using clinical laboratory and morphological analyses]
Aim:
Analysis of long-term outcomes of carriage of hepatitis B virus surface antigen (HBsAg).
Material And Methods:
Complete clinical, device, serological and partial morphological examinations of patients with latent form of HBV infection were performed 16-22 years after the infection with HBV.
Results:
Progression to chronic viral hepatitis (morphologically--hepatitis B) with a trend to annular hepatic tissue rearrangement was stated in all the examinees. Despite the development of chronic hepatitis, serological profile and PCR indicated HBV elimination.
Conclusion:
All patients with latent HBV infection need regular observation because in the absence of symptoms worsening of clinico-biochemical and morphological indices takes place. Therefore, these patients should receive specific antiviral therapy.