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Sarcopenia and hypertrophy: a role for insulin-like growth factor-1 in aged muscle?
Mahjabeen Hameed1, Stephen D R Harridge, Geoffrey Goldspink
1Department of Anatomy and Developmental Biology, Royal Free & University College Medical School, University College London, England.
Exercise and Sport Sciences Reviews
|January 25, 2002
Abstract:
Sarcopenia is the loss of muscle mass associated with the aging process. Although systemic or circulating growth hormone and insulin-like growth factor-1 levels fall as we age, this is likely to be of lesser importance in regard to muscle mass than the role of locally produced insulin-like growth factor-1s generated in the muscle in response to exercise.