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Angioid streaks. II. Fluorescein angiographic features
Archives of Ophthalmology (Chicago, Ill. : 1960)
|October 1, 1975
Summary
This study reveals angioid streaks often show early hypofluorescence, suggesting breaks in Bruch membrane and choriocapillaris nonperfusion. Adjacent areas may be hyperfluorescent due to retinal pigment epithelium changes.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Angioid streaks are a pathological finding in the eye.
- Previous reports on fluorescein angiography of angioid streaks are varied.
- Understanding the angiographic features is crucial for diagnosis and management.
Purpose of the Study:
- To analyze fluorescein angiographic findings in patients with angioid streaks.
- To investigate the underlying mechanisms of observed angiographic patterns.
- To correlate angiographic features with potential histopathological changes.
Main Methods:
- Retrospective analysis of fluorescein angiographic sequences.
- Evaluation of 31 patients diagnosed with angioid streaks.
- Correlation of angiographic patterns with clinical presentation.
Main Results:
- Angioid streaks typically exhibited an early central hypofluorescence, contrary to prior reports.
- Hypofluorescence was attributed to breaks in Bruch membrane and choriocapillaris separation, leading to nonperfusion.
- Adjacent hyperfluorescent areas suggested abnormal retinal pigment epithelium and thickened Bruch membrane.
- Peau d'orange and isolated focal lesions showed distinct hypofluorescent and hyperfluorescent patterns, respectively, linked to Bruch membrane integrity.
Conclusions:
- Early central hypofluorescence is a characteristic finding in angioid streaks.
- Fluorescein angiography provides insights into the structural integrity of Bruch membrane and choriocapillaris.
- The observed patterns correlate with potential pathological alterations in the retinal pigment epithelium and Bruch membrane.