Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improved subtraction by adiabatic FAIR perfusion imaging.

Janneke Schepers1, Michael Garwood, Boudewijn van der Sanden

  • 1Department of Experimental in vivo NMR, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands. janneke@invivonmr.uu.nl

Magnetic Resonance in Medicine
|January 26, 2002
PubMed
Summary

Adiabatic principles reduce arterial spin labeling errors. This new FAIR imaging method minimizes slice profile mismatches, significantly decreasing subtraction errors for better perfusion measurements.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling of Fiber Orientation-Dependent R1 Relaxation in Human White Matter In Vivo Within The Framework of The Transient Hydrogen Bond Model.

Magnetic resonance in medicine·2026
Same author

Consistent Quadratic Phase Formation in 3D Fast Spin Echo Using Frequency-Modulated RF Pulses.

Magnetic resonance in medicine·2026
Same author

Designing B<sub>1</sub>-Selective Pulses by Frequency Modulating in a Second Rotating Frame.

Magnetic resonance in medicine·2026
Same author

Flow-suppressed 2D spin-echo imaging with high tolerance to B<sub>1</sub> inhomogeneity using hyperbolic secant pulses.

Magnetic resonance in medicine·2025
Same author

Fiber orientation-dependent T<sub>1</sub> angular features in human white matter at 1.5 T, 3 T, and 7 T.

Magnetic resonance in medicine·2025
Same author

Exact analytical solutions of the Bloch equation for the hyperbolic-secant and chirp pulses.

Magnetic resonance in medicine·2025

Area of Science:

  • Magnetic Resonance Imaging
  • Physiology
  • Biomedical Engineering

Background:

  • Pulsed arterial spin labeling (ASL) techniques like FAIR are crucial for non-invasive perfusion imaging.
  • Slice profile mismatches in FAIR imaging introduce non-perfusion-related signal offsets, complicating accurate measurements.
  • Existing methods to reduce these subtraction errors have limitations.

Purpose of the Study:

  • To propose a novel acquisition method for FAIR experiments utilizing adiabatic principles.
  • To reduce subtraction errors in FAIR imaging by minimizing the mismatch between imaging and labeling slices.
  • To demonstrate the efficacy of adiabatic pulses in improving FAIR imaging accuracy.

Main Methods:

  • Implementation of adiabatic pulses for both labeling and echo refocusing in FAIR experiments.

Related Experiment Videos

  • Experimental and simulation-based comparison of the proposed adiabatic method against traditional 5-lobe sinc excitation.
  • Quantification of subtraction errors to assess the reduction achieved by the new method.

    • Main Results:

    • Adiabatic pulses enable the use of the same pulse for labeling and echo refocusing.
    • This reduces the mismatch between the imaging and labeling slice profiles.
    • A twofold reduction in subtraction errors was observed compared to 5-lobe sinc excitation, confirmed by both simulation and experimental data.

    Conclusions:

    • The proposed FAIR acquisition method based on adiabatic principles effectively reduces subtraction errors.
    • This technique offers improved accuracy for perfusion imaging using pulsed ASL.
    • Adiabatic pulses represent a promising advancement for minimizing artifacts in FAIR MRI.