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Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
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[Quantitative assessment of beta-cell ultrastructure from mono- and polyhormonal insulinomas]

E V Borodataia1, I A Morozov, L E Gurevich

  • 1M.F. Vladimirsky Moscow Region Research Clinical Institute, 129110, Moscow.

Arkhiv Patologii
|January 29, 2002
PubMed

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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