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[Synthesis of cholesterol-containing cationic amphiphiles with heterocyclic bases]
T V Konstantinova1, V N Klykov, G A Serebrennikova
1Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117571 Russia. konstantinova@httos.mitht.msk.ru
Bioorganicheskaia Khimiia
|January 29, 2002
Abstract:
A number of cationic derivatives of cholesterol containing polar residues of N-methylimidazole, pyridine, N-methylmorpholine, and 4-N,N-dimethyaminopyridine were synthesized by the interaction of the corresponding heterocyclic bases with cholesterol 5-bromopentanoate followed by the treatment with methyl iodide in the case of tertiary amines. In addition, N-(4-cholesteryloxycarbonylbutyl)piperazine was obtained for the preparation of pH-sensitive liposomes.