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Pleomorphic hyalinizing angiectatic tumor.

K Husek1, K Veselý

  • 1I. patologickoanatomický ústav LF MU, Brno.

Ceskoslovenska Patologie
|January 30, 2002
PubMed
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This case report details a pleomorphic hyalinizing angiectatic tumor (PHAT), a rare soft tissue neoplasm. The patient, a 63-year-old male, experienced a successful surgical outcome with no recurrence after 13 months.

Area of Science:

  • Oncology
  • Pathology
  • Dermatology

Background:

  • Pleomorphic hyalinizing angiectatic tumor (PHAT) is a recently identified soft tissue tumor.
  • PHAT presents a diagnostic challenge due to its varied histological features.

Purpose of the Study:

  • To report an additional case of PHAT.
  • To discuss the differential diagnosis of this rare entity.

Main Methods:

  • Case presentation of a 63-year-old male with a subcutaneous forearm tumor.
  • Histopathological and immunohistochemical analysis of the resected tumor.
  • 13-month follow-up for tumor recurrence.

Main Results:

  • Grossly, a well-demarcated ovoid tumor measuring 4.0 x 3.5 x 2.5 cm was removed.

Related Experiment Videos

  • Histology revealed spindle cells, ectatic vessels, fibrin deposits, and thickened hyalinized walls.
  • Immunohistochemistry showed vimentin positivity and negativity for markers including CD34, S100, and smooth-muscle actin.
  • Low mitotic activity (less than 1 per 30 HPF) and low Ki-67 proliferation index (2.6%).

    • Conclusions:

    • The patient achieved a favorable outcome with no recurrence after 13 months.
    • Differential diagnosis includes solitary fibrous tumor, giant-cell angiofibroma, and other spindle cell neoplasms.