Analysis of certain tranquilizers in biological fluids

Area of Science:

• Analytical Chemistry
• Pharmacology
• Medicinal Chemistry

Background:

• Phenothiazines, thioxanthenes, and benzodiazepines are crucial pharmaceutical compounds.
• Accurate analysis is vital for drug development, quality control, and therapeutic monitoring.
• Existing analytical methods require comprehensive review and synthesis.

Purpose of the Study:

• To systematically review and present reported analytical methods for key pharmaceutical derivatives.
• To consolidate information on techniques suitable for analyzing phenothiazines, thioxanthenes, and benzodiazepines.
• To include methods applicable to the analysis of these compounds in biological matrices.

Main Methods:

• Comprehensive literature search across scientific databases.
• Inclusion of analytical techniques reported in 282 references.
• Focus on methods relevant to pharmaceutical analysis and biological fluid analysis.

Main Results:

• A broad spectrum of analytical methodologies for the target compounds has been identified.
• Methods cover various techniques, including chromatography and spectroscopy.
• Adaptation of methods for biological fluid analysis is a key feature.

Conclusions:

• A consolidated overview of analytical methods for phenothiazines, thioxanthenes, and benzodiazepines is provided.
• The review highlights the importance of validated methods for pharmaceutical applications.
• The compilation serves as a valuable resource for researchers in drug analysis and clinical toxicology.