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New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman
Richard E Mewshaw1, Rulin Zhao, Xiaojie Shi
1Global Chemical Sciences Department, Wyeth-Ayerst Research Laboratories, PO Box 42528, Philadelphia, PA 19101-2528, USA. mewshar@war.wyeth.com
Bioorganic & Medicinal Chemistry Letters
|January 30, 2002
Abstract:
Based on the 7-OH-2-(aminomethyl)chroman dopamine D(2) template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4).
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