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Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones
Hea-Young Park Choo1, Mihyun Kim, Sang Kook Lee
1Ewha Womans University, School of Pharmacy, Seoul 120-750, South Korea.
Bioorganic & Medicinal Chemistry
|January 30, 2002
Abstract:
A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.