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Meropenem stability to beta-lactamase hydrolysis and comparative in vitro activity against several
N Franceschini1, B Segatore, M Perilli
1Dipartimento di Scienze e Tecnologie Biomediche, Università dell'Aquila, Via Vetoio, 67100 L'Aquila, Italy.
The Journal of Antimicrobial Chemotherapy
|January 30, 2002
Abstract:
The interaction between meropenem and class A, B, C and D beta-lactamases was studied by a spectrophotometric method. Class A, C and D beta-lactamases were unable to confer in vitro resistance to carbapenems. Surprisingly, several class B metallo-beta-lactamases expressed in Escherichia coli failed to confer resistance when a conventional inoculum (105 cfu/mL) was used.