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Updated: Aug 8, 2026
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Three-Dimensional (3D) Tumor Spheroid Invasion Assay
Published on: May 1, 2015
[Desmoid tumors in three patients]
1Veszprém Megyei Csolnoky Ferenc Kórház, Sebészeti Osztály, 8201 Veszprém, Kórház utca 1.
Magyar Sebeszet
|January 31, 2002
Summary
Desmoid tumors are rare connective tissue growths, occurring frequently in familial adenomatous polyposis (FAP) patients due to APC gene mutations. Early genetic screening and medical management are crucial for FAP patients at high risk of desmoid formation.
Area of Science:
- Oncology
- Genetics
- Surgical Pathology
Background:
- Desmoid tumors are rare connective tissue neoplasms.
- They occur 1000 times more frequently in familial adenomatous polyposis (FAP) patients.
- APC gene mutations are linked to desmoid tumors in FAP, classifying them as an extraintestinal manifestation of Gardner syndrome.
Observation:
- Desmoid tumors exhibit high recurrence rates and rapid growth.
- They are the second leading cause of mortality in FAP patients.
- Genetic testing for FAP patients can identify those at higher risk for desmoid formation.
Findings:
- Medical management of polyposis can delay colectomy, reducing desmoid induction risk.
- Patients with sporadic desmoid tumors require screening for Gardner syndrome manifestations.
- Palliative surgery for intraabdominal desmoids is contraindicated due to tumor progression risk.
Implications:
- Medical treatments (sulindac, tamoxifen), chemotherapy, and radiotherapy can induce remission in inoperable desmoid tumors.
- Genetic screening and proactive management are vital for FAP patients.
- Comprehensive evaluation for Gardner syndrome is recommended for sporadic desmoid tumor patients.
