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Severe diabetes in remission: a Singapore's perspective
1Department of Endocrinology, Singapore General Hospital, Outram Road, Singapore 169608. gecthh@sgh.gov.sg
Annals of the Academy of Medicine, Singapore
|January 31, 2002
Summary
Atypical diabetes, characterized by severe hyperglycemia and prolonged remission, exists in various populations. This finding challenges the classical presentation of Type 1 diabetes and has management implications.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Diabetes Research
Background:
- Diabetic ketoacidosis is typically associated with Type 1 diabetes.
- Atypical diabetes presentations with severe hyperglycemia, ketosis, and subsequent remission are increasingly recognized.
- These cases were previously identified in specific ethnic groups, prompting investigation in other populations.
Purpose of the Study:
- To identify the existence of patients with atypical diabetes in the local population.
- To characterize the clinical features and outcomes of these patients.
Main Methods:
- Retrospective and prospective analysis of patients admitted for diabetic ketoacidosis.
- Recruitment of patients meeting criteria for atypical diabetes from a dedicated database.
Main Results:
- Ten individuals with atypical diabetes were identified, sharing similarities with previously described cases.
- These patients presented with older age of onset, higher BMI, elevated HbA1c, and prolonged remission compared to classical Type 1 diabetes.
Conclusions:
- Atypical diabetes, distinct from classical Type 1 diabetes, is present in this population.
- Awareness of atypical diabetes is crucial for appropriate clinical management and patient care.