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Updated: May 12, 2026
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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Nephron-sparing surgery for renal cell carcinoma
1The Cleveland Clinic Foundation, Urological Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. novicka@ccf.org
Annual Review of Medicine
|January 31, 2002
Summary
Nephron-sparing surgery (NSS) offers effective treatment for localized kidney cancer, preserving kidney function and achieving excellent survival rates. It is a viable alternative to dialysis for select patients.
Area of Science:
- Urology
- Oncology
- Nephrology
Background:
- Localized renal cell carcinoma (RCC) requires effective treatment.
- Nephron-sparing surgery (NSS) is a crucial therapeutic option for localized RCC.
- NSS preserves renal function, especially vital for patients with comorbidities.
Purpose of the Study:
- To evaluate the efficacy of NSS in treating localized renal cell carcinoma.
- To assess NSS as an alternative to renal replacement therapy.
- To determine cancer-specific survival rates and recurrence risks associated with NSS.
Main Methods:
- Review of outcomes for patients undergoing NSS for localized RCC.
- Comparison of NSS with radical nephrectomy.
- Analysis of data for elective partial nephrectomy in small, unifocal tumors.
Main Results:
- NSS provides excellent cancer-specific survival (90%-100%) for selected patients.
- Elective partial nephrectomy for small tumors (< or = 4 cm) has a low recurrence risk (0%-3%).
- Cancer control with NSS is equivalent to radical nephrectomy over five years.
Conclusions:
- NSS is an effective curative therapy for localized renal cell carcinoma.
- NSS preserves renal function and offers excellent oncological outcomes.
- Minimally invasive NSS techniques require further technological advancement and long-term data.
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