Multifactorial analysis of recurrence of cholecy_stolithiasis in Shanghai area

AIM:To explore the risk factors of gallbladder stone recurrence.METHODS:A multifactorial analysis was made for 1058 patients in Shanghai area whose gallbladder stones disappeared after different kinds of nonsurgical therapy,including oral litholytic therapy, extracorporeal shock wave lithotripsy and percutaneous choledocholithotripsy. Serum level of insulin and total bile acid were determined in 122 patients.RESULTS:After 1-8.8 years of follow-up, the recurrence rate of gallbladder stone was 11.6%, 22.4%, 29.5%, 36.4%, 39.3% and 39.7% respectively within 1, 2, 3, 4, 5 and over 5 years. The risk factors for the recurrence are:primary multiple gallstones (P < 0.05); family history of cholecysto-lithiasis (P < 0.05); greasy food intake (P <0.01); low mean value of serum insulin (P < 0.01); and high mean value of total bile acid (P < 0.01).CONCLUSION:The recurrence of cholecystolithiasis is related to overintake of high fat and high cholesterol food, and might also be related to low level of serum insulin.