Effect of amiloride on digitalis-induced electrocardiographic changes

In 10 out of the 13 healthy subjects a single oral dose of 1.25 mg of digoxin induced S-T-J depression and T wave flattening in the exercise ECG. Treatment with potassium-sparing diuretic, amiloride, at a dose of 5 mg twice daily for one week reversed the digoxin-induced S-T-J depression but had no effect on the T wave changes.