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Hyperbaric oxygen therapy for mitomycin C-induced scleral necrosis
Atilla Bayer1, F Mehmet Mutlu, Gungor Sobaci
1Department of Ophthalmology Gulhane Military Medical Academy and Medical School, Ankara, Turkey.
Ophthalmic Surgery and Lasers
|February 1, 2002
Summary
Mitomycin C can cause scleral necrosis after pterygium surgery. Hyperbaric oxygen therapy effectively treated this complication, restoring scleral thickness and function.
Area of Science:
- Ophthalmology
- Regenerative Medicine
Background:
- Mitomycin C is used to prevent pterygium recurrence.
- Scleral necrosis is a serious complication of Mitomycin C treatment.
Observation:
- A patient developed scleral necrosis after pterygiectomy and topical Mitomycin C use.
- Conjunctival flap failures occurred post-necrosis.
Findings:
- Hyperbaric oxygen therapy (HBOT) was administered for 24 sessions.
- The patient's sclera revascularized and regained near-normal thickness.
Implications:
- This case highlights HBOT as a novel and effective treatment for Mitomycin C-induced scleral necrosis.
- Early intervention with HBOT may prevent vision loss from this ophthalmic complication.