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Development and evaluation of matrix and two layered sustained release suppositories of theophylline
S Maity1, B Sa, A K Bandyopadhyay
1Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Abstract:
Theophylline loaded conventional suppositories, sustained release matrix suppositories and sustained release two layered suppositories were prepared using polyethylene glycol 4000 and eudragit RS-100 and their characteristics were evaluated both in-vitro and in-vivo. In comparison to conventional suppositories, the release of the drug from sustained release matrix suppositories was gradual and extended over a period of time. On the other hand two layered suppositories produced an initial quick release followed by extended release of the drug. The in-vivo results were found to correlate with the in-vitro results.
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