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Ivermectin toxicity in 17 collies.

Kate Hopper1, Janet Aldrich, Steve C Haskins

  • 1Veterinary Medical Teaching Hospital, University of California, Davis 95616, USA. khopper@ucdavis.edu

Journal of Veterinary Internal Medicine
|February 2, 2002
PubMed
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Collies are susceptible to ivermectin toxicity, experiencing severe clinical signs and prolonged recovery. Intensive nursing care is crucial for a good prognosis in affected dogs.

Area of Science:

  • Veterinary Medicine
  • Toxicology
  • Pharmacology

Background:

  • Ivermectin is a common anthelminthic in veterinary medicine.
  • Collie breeds exhibit increased sensitivity to ivermectin toxicity.
  • Ivermectin toxicity in Collies can lead to severe clinical manifestations.

Purpose of the Study:

  • To review cases of ivermectin toxicity in Collies presented to a veterinary teaching hospital.
  • To characterize the clinical signs, progression, and outcomes of ivermectin toxicity in Collies.
  • To evaluate the required supportive care and prognosis for Collies with ivermectin toxicity.

Main Methods:

  • Retrospective review of medical records of two groups of Collies with ivermectin toxicity.
  • Analysis of clinical signs, dosage, route of administration, and time of presentation.

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  • Assessment of treatment interventions and patient outcomes.

    • Main Results:

    • Group I (oral ivermectin) showed rapid onset of severe signs; 3/5 dogs required mechanical ventilation and were euthanized, 2/5 recovered in 5-7 days.
    • Group II (subcutaneous ivermectin) presented later with variable severity; all survived but required up to 3 weeks for recovery.
    • Clinical signs in Group II often worsened for approximately 6 days before gradual improvement.

    Conclusions:

    • Collies are prone to severe and prolonged ivermectin toxicity requiring intensive care.
    • Supportive measures including respiratory, cardiovascular, and nutritional support are vital.
    • With appropriate intensive care, the prognosis for complete recovery in Collies with ivermectin toxicity is favorable.