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Related Experiment Videos

Ethnic differences in coronary atherosclerosis.

Matthew J Budoff1, Ted P Yang, Robert M Shavelle

  • 1Division of Cardiology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California 90502-2064, USA. mbudoff@rei.edu

Journal of the American College of Cardiology
|February 2, 2002
PubMed
Summary

Ethnic differences in coronary artery calcification (CAC) and obstructive coronary disease were observed. Whites had a higher atherosclerotic burden than blacks and Hispanics, independent of risk factors.

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Area of Science:

  • Cardiology
  • Radiology
  • Public Health

Background:

  • Electron beam tomography (EBT) quantifies coronary artery calcification (CAC) for cardiac event prognostication.
  • Ethnic disparities in coronary mortality are not fully explained by differences in coronary obstruction or CAC prevalence.
  • Investigating ethnic variations in CAC and obstructive coronary disease is crucial for understanding cardiovascular health disparities.

Purpose of the Study:

  • To investigate ethnic differences in the prevalence of coronary artery calcification (CAC).
  • To determine if ethnic variations in CAC correlate with the degree of coronary obstruction.
  • To assess ethnic differences in atherosclerotic burden among symptomatic patients.

Main Methods:

  • A total of 782 symptomatic patients underwent both electron beam tomography (EBT) and coronary angiography.

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  • Coronary artery calcification (CAC) was quantified using EBT.
  • Significant coronary obstruction was defined as 50% luminal narrowing on angiography.

    • Main Results:

    • Substantial ethnic differences were found in the prevalence of CAC and angiographic stenosis.
    • Whites (n=453) showed higher CAC (84%) and obstruction (71%) rates compared to blacks (n=108; 62% CAC, 49% obstruction) and Hispanics (n=177; 71% CAC, 58% obstruction).
    • These ethnic disparities persisted after controlling for age, gender, and cardiac risk factors.

    Conclusions:

    • Blacks and Hispanics exhibited significantly lower prevalence of CAC and obstructive coronary disease compared to whites.
    • Ethnic differences in risk-factor profiles did not account for the observed disparities in atherosclerotic burden.
    • This study indicates a higher atherosclerotic burden in whites compared to blacks and Hispanics among symptomatic patients undergoing angiography.