A lipid emulsion reduces mortality from clomipramine overdose in rats
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Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
Published on: July 23, 2016
Goor Yoav1, Goor Odelia, Cabilil Shaltiel
1Department of Internal Medicine 6, Tel Aviv Sourasky Medical Centre, Israel.
Abstract:
Tricyclic antidepressants are a common cause of self poisoning. Since these drugs are highly lipid soluble, we examined the interaction between imipramine and a lipid emulsion. Rats were given an iv dose of imipramine with either normal saline or a lipid emulsion as vehicle. The rats who received the lipid emulsion had a significantly lower mortality. The role of lipid emulsions poisoning therapy is reviewed.

