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Published on: February 10, 2014
[The osteoinductivity and the dose-effect relationship with implantation of reconstituted bone xenograft:
1Department of Orthopedics, 202nd Hospital, People's Liberation Army, Shenyang 110003.
Objective:
To observe osteoinductivity and the dose-effect relationship with administration of reconstituted bone xenograft (RBX).
Method:
A posterior thigh muscle pouch model with RBX transplantation was established in BALB/C mice. Samples were treated at regular postoperative intervals for radiologic, histomorphologic and ALP examinations.
Result:
(1) In the groups that had been implanted with RBX, the osteoinductivity was positively correlated with the bBMP contents in RBX (r = 0.7204, P < 0.01), showing a dose-dependent relationship; (2) satisfactory osteogenesis was noted in the RBX I group, whereas no substantial bone formation was seen in the group implanted with bBMP alone apart from some evidence of osteogenic effect; (3) the alkaline phosphatase activity attained its peak on the 7th day postoperatively and kept still higher to the 42nd day.
Conclusion:
RBX is a highly osteoinductive grafting material with the treated homologous cancellous bone being a good slow-delivery carrier which can enhance the osteoinductive capacity of bBMP.
