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Published on: June 19, 2013
Molecular mycology: a genetic toolbox for Histoplasma capsulatum
1Washington University School of Medicine, Dept of Molecular Microbiology, Campus Box 8230, St Louis, MO 63110, USA.
Abstract:
Research in medical mycology has traditionally been a mix of exciting biology and frustrating genetics, although the excitement has been steadily increasing as genetic obstacles have been successfully overcome. Now, a variety of fungal pathogens can be studied using molecular techniques derived from classical bacterial and yeast genetics, but with selective and strategic adaptations. Histoplasma capsulatum is the best-studied of the primary pathogens known as 'dimorphic' fungi, and tailored molecular genetic strategies are beginning to reveal a repertoire of genes and gene products intimately associated with pathogenesis.
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