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Calcium metabolism in space flight.

W F Neuman1

  • 1Department of Radiation Biology and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.

Life Sciences and Space Research
|January 1, 1970
PubMed
Summary

Immobilization causes bone loss and high calcium levels. While diet and exercise may help, discrepancies exist between bone density scans and metabolic studies, suggesting potential hidden bone mineral shifts.

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Area of Science:

  • Space medicine
  • Bone metabolism
  • Physiology

Background:

  • Immobilization is known to cause skeletal substance loss, hypercalcemia, and hypercalciuria.
  • Previous studies reviewed include data from paraplegics, polio patients, fracture patients, and immobilized volunteers.

Purpose of the Study:

  • To review existing data on immobilization-induced bone loss.
  • To report recent bone densitometry and metabolic balance studies in astronauts and volunteers.
  • To investigate discrepancies between bone densitometry and metabolic balance data.

Main Methods:

  • Review of historical data on immobilization and bone loss.
  • Bone densitometry measurements in normal volunteers and astronauts (Gemini IV, V, VII).
  • Metabolic balance studies conducted during the Gemini VII mission.

Main Results:

  • Bone densitometry indicated bone loss in volunteers and astronauts.
  • Metabolic balance studies suggested adequate calcium intake and exercise might control calcium mobilization.
  • Significant discrepancies were observed between bone loss indicated by densitometry and no bone loss shown in balance data.

Conclusions:

  • Adequate calcium intake and programmed exercise may mitigate calcium mobilization during immobilization.
  • Discrepancies between densitometry and balance studies are concerning.
  • Potential for undetected intraskeletal transfers of bone mineral requires further investigation.
Keywords:
NASA Experiment Number M007

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