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Correlation between in vitro and in vivo infectivity of Leishmania infantum clones

S Méndez1, F J Fernández-Pérez, M Santín

  • 1National Institute of Allergy and Infectious Disease, The National Institutes of Health, Bethesda, Maryland 20892, USA.

The Journal of Eukaryotic Microbiology
|February 8, 2002
PubMed

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Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...