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[Measurement of T and DHT contents in normal and diseased human prostate tissues]
Objective:
To measure T and DHT contents in normal and diseased human prostate tissues.
Methods:
Serum and prostatic T and DHT levels were measured in patients with normal, benign prostatic hyperplasia and prostate cancer.
Results:
A decline was observed in serum T level, but no change in DHT concentration with aging. There were no significant differences in both blood T and DHT levels between the patients with BPH or PCA and normal controls. Serum T level remained constant. There were excessive accumulation of DHT in BPH, and cancerous prostate tissues were responsible for the pathogenesis of BPH and PCA. Finasteride treatment did not produce a reduction in prostatic DHT content.
Conclusion:
More than one form of 5a-reductases is responsible for the high level of DHT in the gland.
