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[Expression of tumor metastasis gene MTA 1 in hepatocellular carcinoma: clinical implications]
1Eastern Hepatobilliary Surgery Hospital, Second Military Medical University Shanghai 200438, China.
Objective:
To evaluate the relevance of the expression of tumor metastasis gene metastasis-associated 1 (MTA 1) to HCC metastasis.
Methods:
A fragment of MTA 1 cDNA was synthesized by reverse transcription (RT)-PCR. A DIG-labeled method of in situ hybridisation (ISH) was used to measure semiquantitatively MTA 1 mRNA in formalin-fixed, paraffin-embedded sections.
Results:
Most of MTA 1 mRNA positive cells were located on the border of the tumor in some invasive HCC. High MTA 1 expression was found to correlate significantly with portal venous invasion, intrahepatic metastasis, tumor size or distant metastasis (P < 0.05), but not with gender, cirrhosis or AFP level. It also significantly predicted a shorter survival (P < 0.05).
Conclusion:
The overexpression of MTA 1 correlates closely with the invasion process of HCC.