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Ovarian dysgenesis with balanced autosomal translocation
M S Tullu1, P Arora, R C Parmar
1Genetics Division, Department of Paediatrics, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai - 400 012, India. milindtullu@vsnl.net
Journal of Postgraduate Medicine
|February 8, 2002
Abstract:
Autosomal translocations are rare in the patients with ovarian dysgenesis. An 18-year-old female who presented with primary amenorrhoea had hypergonadotropic hypogonadism and streak ovaries with hypoplastic uterus. Karyotype analysis revealed a balanced autosomal translocation involving chromosomes 1 and 11. The probable role of autosomal translocations in ovarian dysgenesis has been discussed.