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In vivo optical coherence tomography feasibility for bladder disease
Elena V Zagaynova1, Olga S Streltsova, Natalia D Gladkova
1Nizhny Novgorod State Medical Academy and Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia.
The Journal of Urology
|February 8, 2002
Summary
Optical coherence tomography (OCT) reveals distinct bladder tissue patterns. This imaging technique aids in identifying inflammation and malignant changes, guiding biopsies and resection margins.
Area of Science:
- Urology
- Medical Imaging
- Oncology
Background:
- Optical coherence tomography (OCT) offers high-resolution imaging of biological tissues.
- Near-infrared imaging provides cellular-level detail of luminal surfaces.
Purpose of the Study:
- To identify characteristic OCT patterns for bladder inflammation and malignancy.
- To assess OCT's utility in guiding biopsies and surgical resections.
Main Methods:
- OCT imaging of the bladder in 66 patients via cystoscope.
- Acquisition and comparison of 680 OCT images with histological findings.
Main Results:
- Normal bladders show three distinct layers on OCT.
- Inflammatory processes (exudative, proliferative) and squamous metaplasia present unique OCT signatures.
- Transitional cell carcinoma displays disrupted layering and shallow penetration depth.
Conclusions:
- OCT effectively visualizes characteristic patterns of bladder inflammation and malignancy.
- OCT serves as a valuable tool for biopsy guidance and defining resection margins.