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Protective effect of ischemic preconditioning on liver
1Vascular Surgery, Affiliated Renji Hospital, Shanghai Second Medical University, Shanghai, 200001, China.
Objective:
To study the protective effect of ischemic preconditioning (IPC) on the hepatic ischemia reperfusion injury.
Methods:
The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made. All 24 mice were divided randomly into 3 groups and anesthetized by 2% sodium pentobarbital (30-40 mg/kg). The enzyme activity of AST, ALT, LDH, SOD and the content of LPO were assayed respectively. Specimens were observed under transmission electron microscope.
Results:
IPC prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P<0.05), and maintained high level of SOD in the tissues (P<0.05).
Conclusions:
IPC has protective effect on the liver function.