[An experimental study on effect of methazolamide on decreasing intraocular pressure in rabbits]

To study the therapeutic effect of methazolamide on glaucoma.

Various doses of methazolamide were orally administered in rabbits, their effects on high intraocular pressures and on recovery of low intraocular pressures were observed.

The high intraocular pressures were significantly decreased and the maintenance of low intraocular pressure was significantly prolonged by the oral administration of 40, 20, 10 mg/kg of methazolamide. A dose-effect relationship that is the reduction of intraocular pressure increases with the increase of the dosage administration of methazolamide could be observed.

This study indicates that methazolamide might play an effective therapeutic role in glaucoma.