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[Relationship between GSTM1 genotype and susceptibility to senile cataract]
[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|February 12, 2002
Abstract
Objective:
To study the relationship between the glutathione s-transferase gene deletion and cataract formation.
Methods:
Blood cells of total of 77 cases with senile cataract and 76 controls were detected for GSTM1 gene, and the subcapsular epithelial cells of 22 cataract lenses were also detected for GSTM1 gene.
Results:
The GSTM1 gene deletion rate in cataract group was 53.25% and that in the control group was 46.05%, they being not significantly different statistically (chi(2) = 0.750, P > 0.05, OR = 0.75). GSTM1 gene deletion rate in the subcapsular epithelial cells of 20 cases was basically consistent with that in blood cells.
Conclusion:
GSTM1 gene deletion is not related to senile cataract formation.