Related Experiment Videos
Abrogation of Ref1 retrovirus restriction in human cells
Greg Towers1, Mary Collins, Yasuhiro Takeuchi
1Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF, United Kingdom.
Journal of Virology
|February 12, 2002
Abstract:
We have previously described postentry restriction of murine leukemia virus in mammals. Here we characterize the block in human cells. Restricted infection kinetics are multiple hit at high virus dose, and restriction is abrogated by preexposure to restricted virus. We hypothesize that restricted capsid can titrate out the restriction factor.