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Pure red cell aplasia and lupus
George S Habib1, Walid R Saliba, Paul Froom
1Department of Internal Medicine B, Carmel Medical Center, Haifa, Israel. gshabib62@yahoo.com
Seminars in Arthritis and Rheumatism
|February 12, 2002
Summary
Systemic lupus erythematosus (SLE) rarely co-occurs with pure red cell aplasia (PRCA). SLE patients with PRCA show similar clinical and laboratory features to those without PRCA, with reduced pleuritis.
Area of Science:
- Hematology
- Rheumatology
- Internal Medicine
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Pure red cell aplasia (PRCA) is a rare condition characterized by the selective suppression of erythropoiesis.
Observation:
- This review analyzed 23 reported cases of SLE with PRCA from 1966-2000.
- SLE diagnosis often preceded or coincided with PRCA diagnosis.
- Clinical and laboratory features of SLE in these patients were comparable to SLE patients without PRCA.
Findings:
- A decreased frequency of pleuritis was noted in SLE patients with PRCA.
- Trends suggested less proteinuria, hallucinations, thrombocytopenia, and leukopenia.
- The natural history and response to prednisone treatment for PRCA in SLE patients mirrored that of PRCA alone.
Implications:
- The association between SLE and PRCA is uncommon.
- SLE patients with PRCA exhibit similar disease characteristics to those without PRCA, barring reduced pleuritis.
- Treatment outcomes for PRCA in SLE patients are consistent with PRCA without SLE.