Related Experiment Video
Updated: Jun 21, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
[Linkage disequilibrium study of microsatellite markers on chromosome 6 and schizophrenia]
Hong Deng1, Xiehe Liu, Guiqing Cai
1Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. xieheliu@hotmail.com
Objective:
To explore the relationship between the microsatellite markers on chromosome 6 and schizophrenia by linkage disequilibrium analysis.
Methods:
Twenty-eight microsatellite markers on chromosome 6 were evaluated in 115 affected-sib-pair and trios families. Linkage disequilibrium analysis was conducted according to diagnostic categories, Positive and Negative Syndrome Scale (PANSS) and other clinical data by XDT and MAPMAKER/SIBS software system.
Results:
Significant P value (P<0.005) was found in all the four diagnostic categories. Only the locus of D6S1960 showed positive P value (P<0.05) in all the subgroups divided by PANSS scale and the age of onset.
Conclusion:
The area around D6S1960 in short arm of chromosome 6 may contain susceptibility gene of schizophrenia.
Related Concept Videos
Dihybrid Crosses
Sex Linked Disorders
Single Nucleotide Polymorphisms-SNPs
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia

