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Updated: Aug 30, 2026
An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models
Published on: October 20, 2017
The Effectiveness of Ultrasound-Guided Glucose Combined with Mecobalamin Neurolysis in Treating Patients with
Yining Qiu1, Chao Tang1,2, Mi Li1,2
1Department of Neurology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, People's Republic of China.
Objective:
This study aimed to to evaluate the efficacy and safety of hydrodissection in refractory painful peripheral neuropathy over six months, and to explore whether the DCEC ultrasound scoring system predicts treatment response.
Methods:
The study included 57 patients diagnosed with intractable painful peripheral neuropathy confirmed by neuroelectrophysiology who visited the outpatient or inpatient departments of the Affiliated Hospital of Guizhou Medical University from March 2023 to June 2024. All patients underwent nerve ultrasound examination and were scored using the DCEC ultrasound scoring system, as well as neurological function assessments (including the Michigan Neuropathy Screening Tool, Toronto Clinical Scoring Scale, and Short-Form McGill Pain Questionnaire). All patients were divided into two groups: the first group consisted of 18 patients with diabetic painful peripheral neuropathy, and the second group consisted of 39 patients with non-diabetic painful peripheral neuropathy. The adverse reactions and complications of both groups after nerve hydrodissection treatment were recorded. The correlation between nerve ultrasound DCEC scores, Michigan and Toronto scores, and visual analog scale (VAS) and Short-Form McGill scores before and after treatment was analyzed.
Results:
The VAS scores and SF-MPQ scores of both patient groups showed significant improvement at 1, 2, 3, and 6 months after treatment compared to before treatment (P<0.001), but there was no significant difference between the two groups. At 3 and 6 months, the percentage of patients with ≥50% improvement both in VAS scores and SF-MPQ scores were higher in the DPPN group compared to the NDPPN group (P=0.004, P=0.021, P=0.001, P=0.016). The clarity score of nerve ultrasound in the affected limb is correlated with pain improvement after treatment (P=0.015).
Conclusion:
Ultrasound-guided nerve hydrodissection may provide pain relief for patients with intractable painful peripheral neuropathy and has good safety. Further controlled studies are needed to confirm its efficacy.
