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Published on: June 16, 2014
[Risk factors for morbidity and mortality in patients with essential hypertension, followed for 25 years]
1Departamento de Medicina, Campus Centro, Hospital San Borja-Arriarán y Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile. osroman@latinmail.com
Insights
Essential hypertension patients with multiple risk factors face higher mortality. Managing comorbidities alongside blood pressure is crucial for better outcomes in cardiovascular disease management.
Area of Science:
- Cardiology
- Hypertension Research
- Public Health
Context:
- Essential hypertension is a prevalent condition requiring comprehensive risk assessment.
- Therapeutic decisions in hypertensive patients must extend beyond blood pressure control.
- Understanding comorbidities is vital for managing long-term patient outcomes.
Purpose:
- To evaluate the incidence and significance of cardiovascular risk factors in a cohort of essential hypertension patients.
- To identify independent predictors of mortality in treated hypertensive individuals.
Summary:
- A 25-year follow-up of 1,072 essential hypertension patients revealed significant blood pressure reduction.
- Key mortality predictors included pre-existing complications, over three risk factors, age >60, and uncontrolled pressures.
- Common risk factors observed were hypercholesterolemia (56%), obesity (11%), and diabetes (13%).
Impact:
- Findings underscore the importance of a multifactorial approach to managing hypertension.
- Identifies specific patient subgroups at higher risk, enabling targeted interventions.
- Contributes to optimizing treatment strategies for essential hypertension to reduce mortality and morbidity.
Background:
Among hypertensive patients, other risk factors for mortality and morbidity, besides blood pressure, must be considered when therapeutic decisions are done.
Aim:
To assess the incidence and relevance of cardiovascular risk factors in a cohort of patients with essential hypertension.
Material And Methods:
A cohort of 1,072 treated patients with essential hypertension was followed for a period up to 25 years. Four hundred eighty six were men and 586 were women, age ranged from 31 to 70 years. At entry, 56% of subjects did not have any organic complications associated to hypertension (stage I WHO criteria), 30% had mild alterations (Stage II) and 14% had major complications (myocardial infarction, stroke, heart failure or renal failure). Likewise, 43.8% had mild, 14.5%, moderate and 41.7%, severe hypertension. Patients were treated with monotherapy or combined therapy based on diuretics, beta blockers, calcium antagonists and angiotensin converting enzyme inhibitors. Goal of therapy was 140/90 mm Hg. Risk factors associated diseases and complications were registered carefully. Causes of death were obtained from hospital records and death certificates. Mortality was analyzed using life tables (intention to treat method included).
Results:
Blood pressure dropped significantly during follow up from a mean of 182/110 to 154/92 mm Hg. During follow up, 143 patients died and 429 complications (lethal or non lethal) were recorded. Twenty four percent of patients smoked, 24% reported alcohol intake, 56% had hypercholesterolemia, 11% were obese, 13% had diabetes and 3% had gout. The proportional hazard model showed that the existence of previous complications, the presence of more than 3 risk factors, and age over 60 and mean systolic and diastolic pressure during therapy, were independent and significant risk factors for mortality.
Conclusions:
The incidence of risk factors among our hypertensive patients is very similar to that of other national or international cohorts.
Related Concept Videos
Factors affecting Blood pressure
Physiological Factors:
Hypertension and Regulation of Blood Pressure
Hypertension I: Introduction
Hypertension II: Pathophysiology
Hypertension III: Clinical Manifestations and Diagnostic Studies
Chronic Kidney Disease I: Introduction

