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Cytosines do it, thymines do it, even pseudouridines do it--base flipping by an enzyme that acts on RNA
Xiaodong Cheng1, Robert M Blumenthal
1Emory University School of Medicine, Department of Biochemistry, Atlanta, GA 30322, USA.
Structure (London, England : 1993)
|February 13, 2002
Abstract:
In the December 28, 2001 issue of Cell, Hoang and Ferré-D'Amaré report the structure of a tRNA pseudouridine synthase, showing the target uridine flipped out from the tRNA and confirming that base flipping is not limited to enzymes that act on DNA.