Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Concordant CpG island methylation in hyperplastic polyposis.

Annie On-On Chan1, Jean-Pierre J Issa, Jeffrey S Morris

  • 1Department of Pathology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4095, USA.

The American Journal of Pathology
|February 13, 2002
PubMed
Summary

The CpG island methylator phenotype (CIMP) is linked to colorectal cancer. Certain hyperplastic polyps (HPs) show high CIMP, suggesting a patient-specific hypermethylator phenotype contributing to cancer development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Pilot Study of Plasma Cell-Free DNA Fragmentomics in Gallbladder Cancer.

JHEP reports : innovation in hepatology·2026
Same author

ctxR: Utilities for interacting with the CTX APIs.

NAM journal·2026
Same author

Unraveling the nexus: Tumor mutational burden, PD-L1 expression, and oncogenic alterations in non-small cell lung cancer cytology specimens.

Cancer cytopathology·2026
Same author

Growth Hormone Pathway as a Prognostic and Therapeutic Biomarker in Patients With Unresectable Hepatocellular Carcinoma Treated With Radiation Therapy.

Advances in radiation oncology·2026
Same author

Generation of CCR4/CD7 Bispecific CAR-T Cells Resistant to Fratricide and Exhaustion.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Circulating Fibroblast Growth Factor 21 (FGF21) as a Prognostic and Diagnostic Biomarker in Hepatocellular Carcinoma.

Journal of hepatocellular carcinoma·2025

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • CpG island methylator phenotype (CIMP) is a key epigenetic mechanism in colorectal carcinogenesis.
  • The origins and implications of CIMP in precursor lesions like hyperplastic polyps (HPs) remain largely unknown.
  • Understanding CIMP in HPs may reveal early events in colorectal cancer development.

Purpose of the Study:

  • To investigate the prevalence and characteristics of CIMP in hyperplastic polyps (HPs).
  • To determine if CIMP in HPs is associated with specific patient groups or clinicopathological features.
  • To explore the relationship between CIMP in HPs and other colorectal lesions.

Main Methods:

  • Analyzed methylation status of p16, MINT1, MINT2, MINT31, and hMLH1 in 102 HPs, 8 serrated adenomas, 19 tubular adenomas, and 9 adenocarcinomas using methylation-specific PCR.

Related Experiment Videos

  • Compared CIMP status in HPs from patients with multiple/large HPs or hyperplastic polyposis versus sporadic HPs.
  • Assessed correlations between methylation loci, HP methylation status within patients, and association with K-ras mutations.

    • Main Results:

    • Sporadic HPs were CIMP-negative, while 43% of HPs from patients with multiple/large HPs or hyperplastic polyposis were CIMP-high.
    • Concordant methylation was observed across multiple loci within individual HPs and between HPs from the same patient.
    • CIMP-high HPs were associated with right colon predominance, serrated adenomas, and absence of K-ras mutations.

    Conclusions:

    • Findings support the existence of a patient-specific hypermethylator phenotype.
    • This phenotype is characterized by concordant CpG island methylation in multiple HPs and other colorectal lesions.
    • The hypermethylator phenotype likely arises from patient-specific factors, including genetic predisposition or environmental exposures.