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Related Concept Videos

Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...

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Related Experiment Video

Updated: May 12, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

Steps toward percutaneous aortic valve replacement.

Younes Boudjemline1, Philipp Bonhoeffer

  • 1Service de Cardiologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France. Bonhop@gosh.nhs.uk

Circulation
|February 13, 2002
PubMed
Summary
This summary is machine-generated.

Nonsurgical aortic valve replacement is possible in lambs using a percutaneous technique. An orientation mechanism is crucial for successful implantation, avoiding coronary obstruction and ensuring valve function.

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Area of Science:

  • Cardiovascular Surgery
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Surgical aortic valve replacement is the current standard.
  • Transcatheter valve replacement offers new possibilities.
  • Percutaneous aortic valve replacement (PAVR) is under investigation.

Purpose of the Study:

  • To evaluate the feasibility of PAVR in a lamb model.
  • To assess the efficacy of a novel valved stent with an orientation mechanism.

Main Methods:

  • A bovine jugular vein valve was sutured into a stent.
  • Valved stents were implanted in lambs (n=12) in the descending aorta or native aortic position.
  • Group 3 utilized an orientation mechanism for native position implantation.

Main Results:

  • All valves were successfully delivered and functioned well in short-term evaluation.
  • Implantation in the native position without an orientation mechanism led to complications (coronary obstruction, mitral insufficiency, migration, paraprosthetic leak).
  • The orientation mechanism in Group 3 ensured successful implantation without adverse effects.

Conclusions:

  • Nonsurgical aortic valve implantation is feasible in lambs.
  • An orientation mechanism is essential for safe and effective PAVR in the native position.
  • This technique shows promise for future human application.