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Related Experiment Videos

Cutting-edge technology. I. Global gene expression profiling using DNA microarrays.

Mayi Arcellana-Panlilio1, Stephen M Robbins

  • 1Southern Alberta Microarray Facility, Department of Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

American Journal of Physiology. Gastrointestinal and Liver Physiology
|February 14, 2002
PubMed
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DNA microarrays enable genome-wide analysis of gene function by hybridizing nucleic acid fragments. This technology is crucial for understanding biological processes in the postgenomic era.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • The completion of the human genome sequence presents a challenge for functional gene analysis.
  • Understanding gene function requires analyzing biological processes on a genome-wide scale.

Purpose of the Study:

  • To review the technical aspects and applications of DNA microarrays.
  • To discuss factors influencing DNA microarray technology use in the postgenomic era.

Main Methods:

  • DNA microarrays involve ordered arrangements of nucleic acid fragments on a solid support.
  • Parallel analysis of thousands of genes is achieved through specific hybridization.

Main Results:

  • DNA microarrays facilitate the assignment of gene function by analyzing biological processes.

Related Experiment Videos

  • The technology enables genome-wide gene expression profiling.

    • Conclusions:

    • DNA microarrays are a key technology for the postgenomic era.
    • Effective use of DNA microarrays requires understanding their technical aspects and applications.