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Related Experiment Videos

Periodic breathing in the mouse.

Fang Han1, Shyam Subramanian, Edwin R Price

  • 1Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 14, 2002
PubMed
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Genetic factors significantly influence ventilation stability in mice. C57BL/6J mice exhibit unstable breathing (periodic breathing) after hypoxia, unlike A/J mice, indicating a genetic basis for ventilatory control.

Area of Science:

  • Physiology
  • Genetics
  • Respiratory Control

Background:

  • Unstable breathing patterns, such as periodic breathing (PB), can be influenced by genetic factors.
  • C57BL/6J (B6) mice are known to lack short-term potentiation, a characteristic that may predispose them to ventilatory instability.
  • Investigating genetic mechanisms underlying ventilatory control is crucial for understanding respiratory disorders.

Purpose of the Study:

  • To test the hypothesis that brief hypoxia challenges trigger unstable breathing in C57BL/6J (B6) mice.
  • To compare the ventilatory responses of B6 mice with A/J mice, which do not exhibit short-term potentiation.
  • To determine if genetic mechanisms contribute to the inheritance of ventilatory behavior instability.

Main Methods:

  • Ventilatory behavior was recorded using plethysmography in unanesthetized B6 and A/J mice.

Related Experiment Videos

  • Mice were exposed to hypoxic (8% O2) or combined hypoxic/hypercapnic (3% CO2-10% O2) challenges, followed by reoxygenation with 100% O2 or air.
  • Ventilatory responses in recombinant inbred strains derived from B6 and A/J mice were examined after poikilocapnic hypoxia.

    • Main Results:

    • 100% of B6 mice exhibited periodic breathing (PB) upon reoxygenation after 8% O2 exposure, with five showing apnea; no A/J mice displayed this.
    • PB was induced in B6 mice but not A/J mice following a 3% CO2-10% O2 challenge.
    • PB expression varied among recombinant inbred strains and was not linked to resting breathing patterns.

    Conclusions:

    • Significant genetic influences affect the stability of ventilation in mice.
    • B6 mice demonstrate a genetic predisposition to developing periodic breathing under hypoxic conditions.
    • Differences in PB expression between mouse strains highlight the role of genetics in ventilatory control mechanisms.