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[Schistosoma mansoni schistosomiasis].
1Laboratoire de parasitologie-mycologie, INSERM unité 399 (immunologie et génétique des maladies parasitaires) Faculté de médecine, Université de la Méditerranée 13385 Marseille. stephane.ranque@medecine.univ-mrs.fr
La Revue Du Praticien
|February 15, 2002
Summary
Schistosomiasis, a parasitic disease, causes liver fibrosis and portal hypertension due to trapped Schistosoma eggs. Early drug treatment can reverse liver fibrosis, preventing severe complications in millions affected.
Area of Science:
- Parasitology
- Immunology
- Hepatology
Context:
- Schistosomiasis is a major parasitic disease affecting millions globally.
- Pathology involves Schistosoma eggs triggering granulomas and fibrosis in host tissues, particularly the liver.
- Liver fibrosis and portal hypertension are significant complications, leading to mortality.
Purpose:
- To elucidate the pathogenesis of liver fibrosis in schistosomiasis.
- To highlight the genetic control over infection intensity and fibrosis onset in Schistosoma mansoni.
- To emphasize the reversibility of liver fibrosis with timely treatment.
Summary:
- Schistosomiasis pathology is primarily driven by eggs of the Schistosoma genus lodged in tissues.
- Infection with Schistosoma mansoni shows distinct genetic influences on infection intensity and liver fibrosis development.
- Liver fibrosis, a leading cause of death in chronic schistosomiasis, is reversible if treated before hepatic insufficiency.
Impact:
- Understanding the genetic basis of fibrosis can lead to targeted therapies.
- Early diagnosis and treatment of schistosomiasis are crucial for preventing irreversible liver damage.
- This research underscores the importance of antischistosomal drugs in managing schistosomiasis-related morbidity and mortality.