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Botulinum toxin A for palmar hyperhidrosis.
1Department of Dermatology and Allergology, the Friedrich-Schiller-University of Jena, Germany. Wollina-uw@khdf.de
Journal of the European Academy of Dermatology and Venereology : JEADV
|February 15, 2002
Summary
Intracutaneous injections of botulinum toxin A effectively treat severe palmar hyperhidrosis, offering long-term relief with minimal side effects. This treatment significantly reduces sweating for extended periods, improving patient quality of life.
Area of Science:
- Dermatology
- Neurology
Background:
- Severe palmar hyperhidrosis significantly impacts quality of life.
- Limited effective long-term treatments exist for recalcitrant cases.
Purpose of the Study:
- To evaluate the efficacy and safety of intracutaneous botulinum toxin A injections for severe palmar hyperhidrosis.
Main Methods:
- Ten patients with severe palmar hyperhidrosis received 200 U of botulinum toxin A per hand via intracutaneous injections.
- Patients were followed for up to 23 months.
Main Results:
- 100% of patients experienced a significant reduction in sweating within one week.
- The antisudorific effect lasted an average of 12.3 months, with a maximum of 22 months.
- Repeated treatments showed sustained efficacy without antibody induction.
Conclusions:
- Botulinum toxin A injections are a safe and effective long-term treatment for palmar hyperhidrosis.
- Strictly intracutaneous injection of small volumes is recommended.
- No significant acute or long-term side effects were observed, apart from tolerable injection pain.