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Related Experiment Videos

Liver function tests in sickle cell disease.

S Richard1, H H Billett

  • 1Division of Haematology, Department of Medicine, New York Presbyterian Hospital, New York, USA.

Clinical and Laboratory Haematology
|February 15, 2002
PubMed
Summary

Hepatitis C serology in sickle cell disease (SCD) is linked to transfusions, unlike Hepatitis B. Ferritin levels correlate with transfusion units but not liver function tests (LFTs), which are typically normal in SCD patients.

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Area of Science:

  • Hematology
  • Infectious Diseases
  • Hepatology

Background:

  • Sickle cell disease (SCD) patients often require blood transfusions, increasing risks of viral infections.
  • Viral hepatitis, particularly Hepatitis B (HBV) and Hepatitis C (HCV), are significant concerns in transfused populations.
  • Liver dysfunction can be a complication in SCD, but its relationship with viral hepatitis and iron overload requires clarification.

Purpose of the Study:

  • To determine the prevalence of positive viral hepatitis serology in patients with SCD.
  • To investigate the association between abnormal liver function tests (LFTs) and blood transfusions, serum ferritin levels, and viral hepatitis status.
  • To assess LFTs during steady state versus vaso-occlusive crises in SCD.

Main Methods:

  • Retrospective chart review of 141 SCD patients.

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  • Collection of laboratory data including hepatitis serology (HBV, HCV), serum ferritin, and LFTs.
  • Analysis of units of packed red blood cells transfused.

    • Main Results:

    • Positive Hepatitis B core antibodies in 14% and Hepatitis C antibodies in 16.5% of patients.
    • A significant association between positive HCV serology and a higher number of transfusions.
    • Serum ferritin levels correlated with transfusion units (P < 0.003), but LFTs (except alkaline phosphatase) showed no correlation with ferritin or hepatitis serologies.
    • Males had higher rates of positive serology, while females had higher ferritin levels.
    • LFTs did not deteriorate during vaso-occlusive crises.

    Conclusions:

    • HCV serology is linked to transfusion history in SCD, whereas HBV serology is not.
    • Serum ferritin levels reflect transfusion burden but do not directly correlate with LFT abnormalities.
    • LFTs in SCD patients are generally normal and remain stable even during crises.