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A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor
Satoshi Sunami1, Mitsuru Ohkubo, Takeshi Sagara
1Banyu Tsukuba Research Institute, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan. sunamist@banyu.co.jp
Bioorganic & Medicinal Chemistry Letters
|February 15, 2002
Abstract:
Replacement of the thiol groups in 1, a potent and highly selective Candida albicans GGTase I inhibitor discovered through screening, with an imidazole ring was achieved by using solid phase synthesis. A non-thiol compound, 7, was found as a representative of a new class of potent C. albicans GGTase I inhibitor with high selectivity against human GGTase I.