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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Syntheses of novel antimycobacterial combinatorial libraries of structurally diverse substituted pyrimidines by
Arun Kumar1, Sudhir Sinha, Prem M S Chauhan
1Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, U.P., India.
Bioorganic & Medicinal Chemistry Letters
|February 15, 2002
Abstract:
A new pyrimidine based scaffold has been developed by three-component solid-phase syntheses. The utility of scaffolds was demonstrated by synthesizing libraries of 80 substituted pyrimidines (a-p), (a-p), 14(a-p), 15(a-p), 16(a-p). Among 80 compounds screened, six compounds, 12i, 13c, 14d, 14e, 14o, and 15d showed in vitro activity against Mycobacterium tuberculosis (MABA) at a concentration of 50 and 25 microg/mL
