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Meiosis activating sterols derived from diosgenin
Anthony Murray1, Christian Grøndahl, Jan L Ottesen
1Novo Nordisk A/S, Novo Nordisk Park, 2760, Maløv, Denmark. amur@novodisk.com
Bioorganic & Medicinal Chemistry Letters
|February 15, 2002
Abstract:
Continuing research based on the meiosis activation properties of the endogenous sterol FF-MAS is reported. The synthesis and SAR of 16- and 26-substituted sterols are described, utilising diosgenin as starting material. Selected sterols were tested for their ability to induce oocyte maturation in hypoxanthine arrested mouse oocytes in vitro.